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Article

Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands.

The Journal of cell biology - 12 May 2003

Wang Rui-An, Vadlamudi Ratna K, Bagheri-Yarmand Rozita, Beuvink Iwan, Hynes Nancy E, Kumar Rakesh

Abstract excerpt

Although growth factors have been shown to influence mammary gland development, the nature of downstream effectors remains elusive. In this study, we show that the expression of p21-activated kinase (Pak)1, a serine/threonine protein kinase, is activated in mammary glands during pregnancy and lactation. By targeting an ectopic expression of a kinase-dead Pak1 mutant under the control of ovine beta-lactoglobulin...

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Source

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Identifiers

PMID: 12732616
DOI: 10.1083/jcb.200212066
PMCID: PMC2172951

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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