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From Plasminogen to Plasmin: Role of Plasminogen Receptors in Human Cancer

17 Nov 2014

Abstract excerpt

Cell surface-associated proteolysis mediated by plasmin (PLA) is an essential feature of wound healing, angiogenesis and cell invasion, processes that are dysregulated in cancer development, progression and systemic spread. The generation of PLA, initiated by the binding of its precursor plasminogen (PLG) to the cell surface, is regulated by an array of activators, inhibitors and receptors. In this review, we...

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PMID: 25407528
DOI: 10.3390/ijms151121229

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