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Article

P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland.

Molecular endocrinology (Baltimore, Md.) - 1 Jun 2006

Vargo-Gogola Tracy, Heckman Brandy M, Gunther Edward J, Chodosh Lewis A, Rosen Jeffrey M

Abstract excerpt

p190-B Rho GTPase activating protein is essential for mammary gland development because p190-B deficiency prevents ductal morphogenesis. To investigate the role of p190-B during distinct stages of mammary gland development, tetracycline-regulatable p190-B-overexpressing mice were generated. Short-term induction of p190-B in the developing mammary gland results in abnormal terminal end buds (TEBs) that exhibit...

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Identifiers

PMID: 16469769
DOI: 10.1210/me.2005-0426

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Source receipt: pubmed, retrieved 7 Sept 2026.

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