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Article

SynDIG4/Prrt1 Is Required for Excitatory Synapse Development and Plasticity Underlying Cognitive Function.

Cell reports - 27 Feb 2018

Matt Lucas, Kirk Lyndsey M, Chenaux George, Speca David J, Puhger Kyle R, Pride Michael C, Qneibi Mohammad, Haham Tomer, Plambeck Kristopher E, Stern-Bach Yael, Silverman Jill L, Crawley Jacqueline N, Hell Johannes W, Díaz Elva

Abstract excerpt

Altering AMPA receptor (AMPAR) content at synapses is a key mechanism underlying the regulation of synaptic strength during learning and memory. Previous work demonstrated that SynDIG1 (synapse differentiation-induced gene 1) encodes a transmembrane AMPAR-associated protein that regulates excitatory synapse strength and number. Here we show that the related protein SynDIG4 (also known as Prrt1) modifies AMPAR...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29490264
DOI: 10.1016/j.celrep.2018.02.026
PMCID: PMC5856126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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