Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Synaptic scaffold evolution generated components of vertebrate cognitive complexity.

Nature neuroscience - 1 Jan 2013

Nithianantharajah Jess, Komiyama Noboru H, McKechanie Andrew, Johnstone Mandy, Blackwood Douglas H, St Clair David, Emes Richard D, van de Lagemaat Louie N, Saksida Lisa M, Bussey Timothy J, Grant Seth G N

Abstract excerpt

The origins and evolution of higher cognitive functions, including complex forms of learning, attention and executive functions, are unknown. A potential mechanism driving the evolution of vertebrate cognition early in the vertebrate lineage (550 million years ago) was genome duplication and subsequent diversification of postsynaptic genes. Here we report, to our knowledge, the first genetic analysis of a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Association Learning
Share to Conditioning, Classical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Conditioning, Operant

Share to Discrimination, Psychological

Share to Disks Large Homolog 4 Protein

Share to Extinction, Psychological

Share to Guanylate Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 23201973
DOI: 10.1038/nn.3276
PMCID: PMC4131247

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Synaptic scaffold evolution generated components of vertebrate cognitive complexity.PMID 23201973Read ↗

MOLECULAR CORRELATE OF MOUSE EXECUTIVE FUNCTION. TOP-DOWN AND BOTTOM-UP COMPLEMENTATIONS BY PRESYNAPTIC VERTEBRATE BRAIN-SPECIFIC Ntng GENE PARALOGSSemantic proximity Read ↗

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performanceSemantic proximity Read ↗

A human-specific modifier of cortical circuit connectivity and function improves behavioral performanceSemantic proximity Read ↗

Synaptic combinatorial molecular mechanisms generate repertoires of innate and learned behaviorSemantic proximity Read ↗

A combinatorial postsynaptic molecular mechanism converts patterns of nerve impulses into the behavioral repertoireSemantic proximity Read ↗

Mutations in neuroligin-3 in male mice impact behavioral flexibility but not relational memory in a touchscreen test of visual transitive inference.Semantic proximity Read ↗

G2Cdb: the Genes to Cognition database.Semantic proximity Read ↗

Glutamate synapses in human cognitive disorders.Semantic proximity Read ↗

Diversification of behavior and postsynaptic properties by netrin-G presynaptic adhesion family proteins.Semantic proximity Read ↗

Association of mouse Dlg4 (PSD-95) gene deletion and human DLG4 gene variation with phenotypes relevant to autism spectrum disorders and Williams' syndrome.Semantic proximity Read ↗

Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1.Semantic proximity Read ↗

Cognitive Endophenotypes of Modern and Extinct Hominins Associated with <i>NTNG</i> Gene ParalogsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.