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Article

Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships.

The Journal of comparative neurology - 1 Oct 2007

Belichenko Pavel V, Kleschevnikov Alexander M, Salehi Ahmad, Epstein Charles J, Mobley William C

Abstract excerpt

Down syndrome (DS) is caused by trisomy of human chromosome 21. Because Ts65Dn and Ts1Cje mice are segmentally trisomic for a region of mouse chromosome 16, they genetically model DS and are used to study pathogenic mechanisms. Previously, we provided evidence for changes in both the structure and function of pre- and postsynaptic elements in the Ts65Dn mouse. Striking changes were evident in the size of the...

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Identifiers

PMID: 17663443
DOI: 10.1002/cne.21433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships.PMID 17663443Read ↗

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