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Article

The development of therapeutic antibodies that neutralize homologous and heterologous genotypes of dengue virus type 1.

PLoS pathogens - 1 Apr 2010

Shrestha Bimmi, Brien James D, Sukupolvi-Petty Soila, Austin S Kyle, Edeling Melissa A, Kim Taekyung, O'Brien Katie M, Nelson Christopher A, Johnson Syd, Fremont Daved H, Diamond Michael S

Abstract excerpt

Antibody protection against flaviviruses is associated with the development of neutralizing antibodies against the viral envelope (E) protein. Prior studies with West Nile virus (WNV) identified therapeutic mouse and human monoclonal antibodies (MAbs) that recognized epitopes on domain III (DIII) of the E protein. To identify an analogous panel of neutralizing antibodies against DENV type-1 (DENV-1), we immunized...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dengue Virus

Share to Enzyme-Linked Immunosorbent Assay

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Share to Epitopes, B-Lymphocyte

Share to Protein Structure, Tertiary

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Source

Open in PubMed Open full text

Identifiers

PMID: 20369024
DOI: 10.1371/journal.ppat.1000823
PMCID: PMC2848552

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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