Article
Development of Cell Culture-Derived Hemagglutination Antigens for Japanese Encephalitis Virus Genotypes 1 and 3.
Viruses - 3 Aug 2026
Lim Seong-In, Yang Dong-Kun, Kwon Gyeong Hui, Kim Hyobi, Baek Yoon-Gi, Kim Eun-Jung, Park Eun Mee, Moon Soo Hyun, Kim Min Ji, Kim Jae-Myung
Abstract excerpt
Conventional Japanese encephalitis virus (JEV) hemagglutination inhibition (HI) antigens are contingent on sucking mouse brain (SMB), and present ethical and standardization challenges. In this study, we established an alternative cell culture platform using LFBK cells to produce JEV genotype I (GI) and III (GIII) antigens. Viral replication and hemagglutination (HA) activity were evaluated in six cell lines....
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