Article

Enhanced Neutralization of Japanese Encephalitis Virus Using an Engineered VL Double-Domain

2025-09-03

Abstract excerpt

Japanese encephalitis virus (JEV) is an emerging virus responsible for thousands of deaths in Asia; however, an effective treatment has not yet been discovered. JEV envelope (E) proteins play important roles in viral survival and infection. In this study, we isolated scFv- and VL-targeting E proteins using phage display biopanning. The isolated VL was engineered to form VL double domains to increase its neutraliza...

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Literature Corpus work: 1f25bd39-2ed9-5e39-bb52-1241035a07d6
DOI: 10.1101/2025.09.03.673967

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