Article

Neurovirulence of the Australian outbreak Japanese Encephalitis virus genotype 4 is lower compared to genotypes 2 and 3 in mice and human cortical brain organoids

2023-04-27

Abstract excerpt

<h4>SUMMARY</h4> <h4>Background</h4> Human infections with Japanese encephalitis virus (JEV) are a leading cause of viral encephalitis. An unprecedented outbreak of JEV genotype 4 was recently reported in Australia, with an isolate (JEV NSW/22 ) obtained from a stillborn piglet brain. <h4>Methods</h4> Herein we compared the neuropathology of JEV NSW/22 , JEV FU (genotype 2) and JEV Nakayama (genotype 3) in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f7f84e70-9c3a-59a9-89ee-42accbf05e7b
DOI: 10.1101/2023.04.26.538504

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Neurovirulence of the Australian outbreak Japanese Encephalitis virus genotype 4 is lower compared to genotypes 2 and 3 in mice and human cortical brain organoidsDOI 10.1101/2023.04.26.538504Read

Characterisation of a Japanese Encephalitis virus genotype 4 isolate from the 2022 Australian outbreakSemantic proximity Read

Emergence and spread of Japanese encephalitis virus genotype IV in a novel ecosystem: Australia, 2021-2022Semantic proximity Read

A chimeric vaccine derived from Australian genotype IV Japanese encephalitis virus protects mice from lethal challengeSemantic proximity Read

mRNA Vaccine Against Japanese Encephalitis Virus Genotype IV Protects Against Lethal Infection.Semantic proximity Read

Development and characterization of an animal model of Japanese encephalitis virus infection in adolescent C57BL/6 mouse.Semantic proximity Read

Comparative pathogenesis of two lineages of Powassan virus reveals distinct clinical outcome, neuropathology, and inflammationSemantic proximity Read

A chimeric vaccine displaying the prM-E proteins of the Australian genotype IV strain of Japanese encephalitis virus protects mice against lethal challengeSemantic proximity Read

Experimental Infections of Pigs with Japanese Encephalitis Virus Genotype 4Semantic proximity Read

Investigation of Powassan virus lineage II pathogenesis and neurotropism in miceSemantic proximity Read

Japanese encephalitis virus: an emerging and re-emerging virus in AustraliaSemantic proximity Read

Mechanism of neuroinvasion and interferon response in human choroid plexus organoids during Japanese encephalitis virus infectionSemantic proximity Read

First Isolation of Japanese Encephalitis Virus Genotype IV from Mosquitoes in Australia.Semantic proximity Read