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Partial cross-protection between Japanese encephalitis virus genotype I and III in mice

2 Aug 2019

Abstract excerpt

Genotype III (GIII) Japanese encephalitis virus (JEV) predominance has gradually been replaced by genotype I (GI) over the last 20 years in many Asian countries. This genotype shift raises concerns about the protective efficacy of Japanese encephalitis (JE) vaccines, as all of the currently licensed JE vaccines are derived from GIII strains. In this study, we conducted vaccination-challenge protection assays to...

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PMID: 31374086
DOI: 10.1371/journal.pntd.0007601

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