Article
Dysregulated invertebrate tropomyosin-dectin-1 interaction confers susceptibility to allergic diseases.
Science immunology - 23 Feb 2018
Gour Naina, Lajoie Stephane, Smole Ursula, White Marquitta, Hu Donglei, Goddard Pagé, Huntsman Scott, Eng Celeste, Mak Angel, Oh Sam, Kim Jung-Hyun, Sharma Annu, Plante Sophie, Salem Ikhlass Haj, Resch Yvonne, Xiao Xiao, Yao Nu, Singh Anju, Vrtala Susanne, Chakir Jamila, Burchard Esteban G, Lane Andrew P, Wills-Karp Marsha
Abstract excerpt
The key factors underlying the development of allergic diseases-the propensity for a minority of individuals to develop dysfunctional responses to harmless environmental molecules-remain undefined. We report a pathway of immune counter-regulation that suppresses the development of aeroallergy and shrimp-induced anaphylaxis. In mice, signaling through epithelially expressed dectin-1 suppresses the development of...
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