T-cell–intrinsic Tif1α/Trim24 regulates IL-1R expression on T H 2 cells and T H 2 cell-mediated airway allergy

Abstract excerpt

There is a paucity of new therapeutic targets to control allergic reactions and forestall the rising trend of allergic diseases. Although a variety of immune cells contribute to allergy, cytokine-secreting αβ(+)CD4(+) T-helper 2 (TH2) cells orchestrate the type-2-driven immune response in a large proportion of atopic asthmatics. To identify previously unidentified putative targets in pathogenic TH2 cells, we...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Asthma and respiratory diseases
• Share to IL-33, ST2, and ILC Pathways
• Share to Immune Cell Function and Interaction