Article
Genetic mutations associated with lung cancer metastasis to the brain.
Mutagenesis - 13 Apr 2018
Aljohani Hashim M, Aittaleb Mohamed, Furgason John M, Amaya Peter, Deeb Ayham, Chalmers Jeffery J, Bahassi El Mustapha
Abstract excerpt
Approximately 90% of all cancer deaths arise from the metastatic spread of primary tumours. Of all the processes involved in carcinogenesis, local invasion and the formation of metastases are clinically the most relevant, but they are the least well understood at the molecular level. As a barrier to metastasis, cells normally undergo an apoptotic process known as 'anoikis', in circulation. The recent...
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