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Article

Differences in Genomic Alterations Between Brain Metastases and Primary Tumors.

Neurosurgery - 16 Feb 2021

Dono Antonio, Takayasu Takeshi, Yan Yuanqing, Bundrant Bethany E, Arevalo Octavio, Lopez-Garcia Carlos A, Esquenazi Yoshua, Ballester Leomar Y

Abstract excerpt

BACKGROUND: Brain metastases (BMs) occur in ∼1/3 of cancer patients and are associated with poor prognosis. Genomic alterations contribute to BM development; however, mutations that predispose and promote BM development are poorly understood. OBJECTIVE: To identify differences in genomic alterations between BM and primary tumors. METHODS: A retrospective cohort of 144 BM patients were tested for genomic...

Topics

Adult
Aged
BRCA2 Protein
Brain Neoplasms
Cohort Studies
Cyclin-Dependent Kinases
Female
Genomics
High-Throughput Nucleotide Sequencing
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mutation

Neoplasms

Receptor, ErbB-2

Retrospective Studies

Source

Identifiers

PMID: 33369669
DOI: 10.1093/neuros/nyaa471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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