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Article

Spectrum of gene mutations detected by next generation exome sequencing in brain metastases of lung adenocarcinoma.

European journal of cancer (Oxford, England : 1990) - 1 Sept 2015

Preusser Matthias, Berghoff Anna S, Koller Romina, Zielinski Christoph C, Hainfellner Johannes A, Liebmann-Reindl Sandra, Popitsch Niko, Geier Christoph B, Streubel Berthold, Birner Peter

Abstract excerpt

BACKGROUND: Brain metastases (BM) are a life-threatening complication. We aimed to analyse gene mutations in lung adenocarcinoma BM. METHODS: We performed next generation sequencing (NGS) of a pre-defined set of 48 cancer-related genes in a cohort of 76 neurosurgical lung adenocarcinoma BM specimens using a cancer specific gene panel on the MiSeq platform (Illumina, San Diego, CA). NGS results were statistically...

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Identifiers

PMID: 26164066
DOI: 10.1016/j.ejca.2015.06.107

Genes

EGFR
KRAS
ALK
BRAF
FGFR1
MET
ROS1
SMO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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