Article
Profiles of brain metastases: Prioritization of therapeutic targets.
International journal of cancer - 1 Dec 2018
Ferguson Sherise D, Zheng Siyuan, Xiu Joanne, Zhou Shouhao, Khasraw Mustafa, Brastianos Priscilla K, Kesari Santosh, Hu Jethro, Rudnick Jeremy, Salacz Michael E, Piccioni David, Huang Suyun, Davies Michael A, Glitza Isabella C, Heymach John V, Zhang Jianjun, Ibrahim Nuhad K, DeGroot John F, McCarty Joseph, O'Brien Barbara J, Sawaya Raymond, Verhaak Roeland G W, Reddy Sandeep K, Priebe Waldemar, Gatalica Zoran, Spetzler David, Heimberger Amy B
Abstract excerpt
We sought to compare the tumor profiles of brain metastases from common cancers with those of primary tumors and extracranial metastases in order to identify potential targets and prioritize rational treatment strategies. Tumor samples were collected from both the primary and metastatic sites of nonsmall cell lung cancer, breast cancer and melanoma from patients in locations worldwide, and these were submitted to...
Topics
- Aged
- Brain Neoplasms
- Female
- Gene Expression
- Humans
- Male
- Middle Aged
- Mutation
- Neoplasm Metastasis