Article
A haplotype at the PARK3 locus influences onset age for Parkinson's disease: the GenePD study.
Neurology - 9 Dec 2003
Karamohamed S, DeStefano A L, Wilk J B, Shoemaker C M, Golbe L I, Mark M H, Lazzarini A M, Suchowersky O, Labelle N, Guttman M, Currie L J, Wooten G F, Stacy M, Saint-Hilaire M, Feldman R G, Sullivan K M, Xu G, Watts R, Growdon J, Lew M, Waters C, Vieregge P, Pramstaller P P, Klein C, Racette B A, Perlmutter J S, Parsian A, Singer C, Montgomery E, Baker K, Gusella J F, Fink S J, Myers R H, Herbert A
Abstract excerpt
OBJECTIVE: To identify a haplotype influencing onset age for Parkinson's disease (PD) in the PARK3 region on chromosome 2p13. METHODS: Single nucleotide polymorphisms (SNP) spanning 2.2 Mb and located in or near potential candidate genes were used to fine map the PARK3 region in 527 patients with familial PD, from 264 families. RESULTS: TT homozygotes for rs1876487 (G/T) had a 7.4-year younger mean age at onset...
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