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Article

Association of Parkinson disease age of onset with DRD2, DRD3 and GRIN2B polymorphisms.

Parkinsonism & related disorders - 1 Jan 2016

Hassan Anhar, Heckman Michael G, Ahlskog J E, Wszolek Zbigniew K, Serie Daniel J, Uitti Ryan J, van Gerpen Jay A, Okun Michael S, Rayaprolu Sruti, Ross Owen A

Abstract excerpt

INTRODUCTION: Dopamine and glutamate are crucial neurotransmitters in Parkinson disease (PD). While recent large meta-analyses reported that genetic variation of dopamine (DRD2, DRD3) and glutamine (NMDA, GRIN2B) neurotransmitter receptors was not associated with PD risk, they could conceivably influence PD phenotype. We studied the association of these receptor polymorphisms relating to PD age of onset. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26627941
DOI: 10.1016/j.parkreldis.2015.11.016
PMCID: PMC5954834

Genes

DRD2
DRD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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