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Article

Effects of COMT genotype and tolcapone on lapses of sustained attention after sleep deprivation in healthy young men.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jun 2018

Valomon Amandine, Holst Sebastian C, Borrello Alessandro, Weigend Susanne, Müller Thomas, Berger Wolfgang, Sommerauer Michael, Baumann Christian R, Landolt Hans-Peter

Abstract excerpt

Tolcapone, a brain penetrant selective inhibitor of catechol-O-methyltransferase (COMT) devoid of psychostimulant properties, improves cognition and cortical information processing in rested volunteers, depending on the genotype of the functional Val158Met polymorphism of COMT. The impact of this common genetic variant on behavioral and neurophysiological markers of increased sleep need after sleep loss is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29472644
DOI: 10.1038/s41386-018-0018-8
PMCID: PMC5983551

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Effects of COMT genotype and tolcapone on lapses of sustained attention after sleep deprivation in healthy young men.PMID 29472644Read ↗

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