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Article

Functional Polymorphisms in Dopaminergic Genes Modulate Neurobehavioral and Neurophysiological Consequences of Sleep Deprivation.

Scientific reports - 10 Apr 2017

Holst Sebastian C, Müller Thomas, Valomon Amandine, Seebauer Britta, Berger Wolfgang, Landolt Hans-Peter

Abstract excerpt

Sleep deprivation impairs cognitive performance and reliably alters brain activation in wakefulness and sleep. Nevertheless, the molecular regulators of prolonged wakefulness remain poorly understood. Evidence from genetic, behavioral, pharmacologic and imaging studies suggest that dopaminergic signaling contributes to the behavioral and electroencephalographic (EEG) consequences of sleep loss, although direct...

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Source

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Identifiers

PMID: 28393838
DOI: 10.1038/srep45982
PMCID: PMC5385564

Genes

DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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