Article
DRD2 C957T genotype modulates the time-on-task effect during total sleep deprivation.
Chronobiology international - 1 Jan 2000
Muck Rachael A, Van Dongen Hans P A, Schmidt Michelle A, Wisor Jonathan P, Layton Matthew E, DePriest Dawn M, Honn Kimberly A, Satterfield Brieann C
Abstract excerpt
Total sleep deprivation (TSD) and time-on-task (TOT), especially in combination, increase cognitive instability and cause performance impairment. There are large inter-individual differences in TSD and TOT effects which, in part, have a genetic basis. Here, we show that the dopamine receptor D2 C957T genetic polymorphism predicts the magnitude of the TOT effect on a psychomotor vigilance test (PVT) during 38 h of...
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