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Article

Tolcapone, COMT polymorphisms and pharmacogenomic treatment of schizophrenia.

Pharmacogenomics - 1 Apr 2011

Bitsios Panos, Roussos Panos

Abstract excerpt

It is widely accepted that abnormal prefrontal cortex biology resulting in deficient cognition is a primary problem in schizophrenia and that all currently available antipsychotics fail to improve cognitive and negative symptoms originating from this deficit. Evidence from basic science has revealed the importance of prefrontal dopamine signaling for optimal prefrontal function. This article describes succinctly...

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Source

Identifiers

PMID: 21521027
DOI: 10.2217/pgs.10.206

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tolcapone, COMT polymorphisms and pharmacogenomic treatment of schizophrenia.PMID 21521027Read ↗

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Genotype-Dependent Effects of COMT Inhibition on Cognitive Function in a Highly Specific, Novel Mouse Model of Altered COMT Activity.Semantic proximity Read ↗

Effects of COMT genotype on cognitive ability and functional capacity in individuals with schizophrenia.Semantic proximity Read ↗

Tolcapone improves cognition and cortical information processing in normal human subjects.Semantic proximity Read ↗

The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons.Semantic proximity Read ↗

Schizophrenia, the prefrontal cortex, and a mechanism of genetic susceptibility.Semantic proximity Read ↗

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A novel protein isoform of catechol O-methyltransferase (COMT): brain expression analysis in schizophrenia and bipolar disorder and effect of Val158Met genotype.Semantic proximity Read ↗

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