Article
p204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice.
EBioMedicine - 1 Mar 2018
Yi Young-Su, Jian Jinlong, Gonzalez-Gugel Elena, Shi Yong-Xiang, Tian Qingyun, Fu Wenyu, Hettinghouse Aubryanna, Song Wenhao, Liu Ronghan, He Michun, Qi Huabing, Yang Jing, Du Xiaolan, Xiao GuoZhi, Chen Lin, Liu Chuan-Ju
Abstract excerpt
p204, a murine member of an interferon-inducible p200 family, was reported to recognize intracellular viral and bacterial DNAs, however, its role in the innate immunity in vivo remains unknown due to the lack of p204-deficient animal models. In this study we first generated the p204-/- mice. Unexpectedly, p204 deficiency led to significant defect in extracellular LPS signaling in macrophages, as demonstrated by...
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