Article

TLR4 Overexpression Aggravates Bacterial Lipopolysaccharide-Induced Apoptosis via Excessive Autophagy and Nf-κB/Mapk Signaling in Transgenic Mammal Models

2023-05-30

Abstract excerpt

Gram-negative bacterial infections pose a significant threat to public health. Toll-like receptor 4 (TLR4) recognizes bacterial lipopolysaccharide (LPS) and induces innate immune responses, autophagy and cell death, which have major impacts on the body physiological homeostasis. However, the role of TLR4 in bacterial LPS-induced autophagy and apoptosis in large mammals remains unknown, which are closer to humans t...

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Literature Corpus work: ca4bc6d7-7c6e-5a19-913a-1e50dcb419c3
DOI: 10.20944/preprints202305.2117.v1

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