Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tlr4: central component of the sole mammalian LPS sensor.

Current opinion in immunology - 1 Feb 2000

Beutler B

Abstract excerpt

Mutations of the mouse Lps locus abolish responses to lipopolysaccharide (LPS). Positional cloning work has revealed that Lps encodes the Toll-like receptor 4 (Tlr4), which functions as the transmembrane component of the LPS receptor complex, an unduplicated pathway for the detection of endotoxin. The structurally related protein Tlr2 makes no contribution to LPS signal transduction.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, Recessive
Share to Insect Proteins
Share to Lipopolysaccharide Receptors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lipopolysaccharides

Share to Models, Immunological

Share to Toll-Like Receptor 2

Share to Toll-Like Receptor 4

Share to Toll-Like Receptors

Source

Identifiers

PMID: 10679411
DOI: 10.1016/s0952-7915(99)00046-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tlr4: central component of the sole mammalian LPS sensor.PMID 10679411Read ↗

Positional cloning of Lps, and the general role of toll-like receptors in the innate immune response.Semantic proximity Read ↗

Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor.Semantic proximity Read ↗

Human Toll-like receptor 4 recognizes host-specific LPS modificationsSemantic proximity Read ↗

Expression level of human TLR4 rather than sequence is the key determinant of LPS responsiveness.Semantic proximity Read ↗

Toll-like receptor signaling in sepsisSemantic proximity Read ↗

Toll-like receptors: how they work and what they do.Semantic proximity Read ↗

Critical role for Ets, AP-1 and GATA-like transcription factors in regulating mouse Toll-like receptor 4 (Tlr4) gene expression.Semantic proximity Read ↗

Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening.Semantic proximity Read ↗

Mal, more than a bridge to MyD88Semantic proximity Read ↗

Identification and characterization of zebrafish Tlr4 co-receptor Md-2Semantic proximity Read ↗

Genes other than TLR4 are involved in the response to inhaled LPS.Semantic proximity Read ↗

Expression of toll-like receptor 4 and endotoxin responsiveness in mice during perinatal period.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.