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Article

Inducible Major Vault Protein Plays a Pivotal Role in Double-Stranded RNA- or Virus-Induced Proinflammatory Response.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2016

Peng Nanfang, Liu Shi, Xia Zhangchuan, Ren Sheng, Feng Jian, Jing Mingzhen, Gao Xin, Wiemer Erik A C, Zhu Ying

Abstract excerpt

Pathogen invasion triggers robust antiviral cytokine production via different transcription factor signaling pathways. We have previously demonstrated that major vault protein (MVP) induces type I IFN production during viral infection; however, little is known about the role of MVP in proinflammatory responses. In this study, we found in vitro that expression of MVP, IL-6, and IL-8 was inducible upon dsRNA...

Read the complete abstract on PubMed

Topics

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Share to CCAAT-Enhancer-Binding Protein-beta
Share to Immunity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza A virus

Share to Leukocytes, Mononuclear

Share to Orthomyxoviridae Infections

Share to RNA, Double-Stranded

Share to RNA, Small Interfering

Share to Transcription Factor AP-1

Source

Identifiers

PMID: 26843330
DOI: 10.4049/jimmunol.1501481

Genes

MVP
EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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