Article
Arginine methylation of the C-terminus RGG motif promotes TOP3B topoisomerase activity and stress granule localization.
Nucleic acids research - 6 Apr 2018
Huang Lifeng, Wang Zhihao, Narayanan Nithya, Yang Yanzhong
Abstract excerpt
DNA topoisomerase 3B (TOP3B) is unique among all mammalian topoisomerases for its dual activities that resolve both DNA and RNA topological entanglements to facilitate transcription and translation. However, the mechanism by which TOP3B activity is regulated is still elusive. Here, we have identified arginine methylation as an important post-translational modification (PTM) for TOP3B activity. Protein arginine...
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