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A dual-activity topoisomerase complex regulates mRNA translation and turnover

24 Jun 2022

Abstract excerpt

Topoisomerase 3β (TOP3B) and TDRD3 form a dual-activity topoisomerase complex that interacts with FMRP and can change the topology of both DNA and RNA. Here, we investigated the post-transcriptional influence of TOP3B and associated proteins on mRNA translation and turnover. First, we discovered that in human HCT116 colon cancer cells, knock-out (KO) of TOP3B had similar effects on mRNA turnover and translation...

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PMID: 35748872
DOI: 10.1093/nar/gkac538

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