Article

A dual-activity topoisomerase complex regulates translation and abundance of mRNAs important for psychiatric disorders

2022-03-25

Abstract excerpt

<title>Abstract</title> <p>Topoisomerase 3b (TOP3B)-TDRD3 is a dual-activity topoisomerase complex in animals that can change topology for both DNA and RNA. A current hypothesis proposes that this complex interacts with Fragile X mental retardation protein, FMRP, to regulate mRNA translation. Here we examined this hypothesis by identifying TOP3B-TDRD3-bound mRNAs in human HCT116 cells; and analyzing the effect of...

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Literature Corpus work: b04d8a21-26dd-5ed1-93d5-1bed7a01edec
DOI: 10.21203/rs.3.rs-1054387/v2

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