Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single Nucleotide Polymorphism Facilitated Down-Regulation of the Cohesin Stromal Antigen-1: Implications for Colorectal Cancer Racial Disparities.

Neoplasia (New York, N.Y.) - 1 Mar 2018

Datta Somenath, Sherva Richard M, De La Cruz Mart, Long Michelle T, Roy Priya, Backman Vadim, Chowdhury Sanjib, Roy Hemant K

Abstract excerpt

The biological underpinnings for racial disparities in colorectal cancer (CRC) incidence remain to be elucidated. We have previously reported that the cohesin SA-1 down-regulation is an early event in colon carcinogenesis which is dramatically accentuated in African-Americans. In order to investigate the mechanism, we evaluated single nucleotide polymorphisms (SNPs) for association with SA-1-related outcomes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomal Proteins, Non-Histone

Share to Cohesins

Share to Colorectal Neoplasms

Share to Down-Regulation

Share to HCT116 Cells

Share to MicroRNAs

Source

Open in PubMed Open full text

Identifiers

PMID: 29471289
DOI: 10.1016/j.neo.2018.01.003
PMCID: PMC5883624

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single Nucleotide Polymorphism Facilitated Down-Regulation of the Cohesin Stromal Antigen-1: Implications for Colorectal Cancer Racial Disparities.PMID 29471289Read ↗

Higher Order Chromatin Modulator Cohesin SA1 Is an Early Biomarker for Colon Carcinogenesis: Race-Specific ImplicationsSemantic proximity Read ↗

Functional annotation of colon cancer risk SNPs.Semantic proximity Read ↗

Enhancer-gene regulatory interactions in colorectal cancer revealed through genome-wide CRISPRi perturbationsSemantic proximity Read ↗

Overexpression of the cohesin-core subunit SMC1A contributes to colorectal cancer developmentSemantic proximity Read ↗

Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestriesSemantic proximity Read ↗

Mutant cohesin drives chromosomal instability in early colorectal adenomas.Semantic proximity Read ↗

Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries.Semantic proximity Read ↗

CTCF/cohesin-binding sites are frequently mutated in cancer.Semantic proximity Read ↗

Functional impact of cancer-associated cohesin variants on gene expression and cellular identity.Semantic proximity Read ↗

Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells.Semantic proximity Read ↗

Role of cancer stem cells in racial disparity in colorectal cancer.Semantic proximity Read ↗

SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-2′deoxycytidine to increase SPARC expression and improve therapy responseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.