Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant cohesin drives chromosomal instability in early colorectal adenomas.

Human molecular genetics - 20 Dec 2014

Cucco Francesco, Servadio Adele, Gatti Veronica, Bianchi Paolo, Mannini Linda, Prodosmo Andrea, De Vitis Elisa, Basso Gianluca, Friuli Alessandro, Laghi Luigi, Soddu Silvia, Fontanini Gabriella, Musio Antonio

Abstract excerpt

Chromosome missegregation leads to chromosomal instability (CIN), thought to play a role in cancer development. As cohesin functions in guaranteeing correct chromosome segregation, increasing data suggest its involvement in tumorigenesis. In a screen of a large series of early colorectal adenomas, a precocious step during colorectal tumorigenesis, we identified 11 mutations in SMC1A core cohesin subunit. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to Aneuploidy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomal Instability

Share to Chromosomal Proteins, Non-Histone

Share to Chromosome Segregation

Share to Precancerous Conditions

Share to Primary Cell Culture

Share to Structural Maintenance of Chromosome Protein 1

Source

Identifiers

PMID: 25080505
DOI: 10.1093/hmg/ddu394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant cohesin drives chromosomal instability in early colorectal adenomas.PMID 25080505Read ↗

Overexpression of the cohesin-core subunit SMC1A contributes to colorectal cancer developmentSemantic proximity Read ↗

Role of SMC1A overexpression as a predictor of poor prognosis in late stage colorectal cancerSemantic proximity Read ↗

The chromosomal instability pathway in colon cancer.Semantic proximity Read ↗

Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers.Semantic proximity Read ↗

The expanding universe of cohesin functions: a new genome stability caretaker involved in human disease and cancer.Semantic proximity Read ↗

Higher Order Chromatin Modulator Cohesin SA1 Is an Early Biomarker for Colon Carcinogenesis: Race-Specific ImplicationsSemantic proximity Read ↗

Cohesin Rad21 Mediates Loss of Heterozygosity and Is Upregulated via Wnt Promoting Transcriptional Dysregulation in Gastrointestinal TumorsSemantic proximity Read ↗

Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis.Semantic proximity Read ↗

Single Nucleotide Polymorphism Facilitated Down-Regulation of the Cohesin Stromal Antigen-1: Implications for Colorectal Cancer Racial Disparities.Semantic proximity Read ↗

Genome stability: What we have learned from cohesinopathies.Semantic proximity Read ↗

Cohesin Mutations in Cancer.Semantic proximity Read ↗

Early genetic aberrations in patients with sporadic colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.