Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of the cohesin-core subunit SMC1A contributes to colorectal cancer development

1 Mar 2019

Abstract excerpt

BACKGROUND: Cancer cells are characterized by chromosomal instability (CIN) and it is thought that errors in pathways involved in faithful chromosome segregation play a pivotal role in the genesis of CIN. Cohesin forms a large protein ring that binds DNA strands by encircling them. In addition to this central role in chromosome segregation, cohesin is also needed for DNA repair, gene transcription regulation and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Genetic factors in colorectal cancer
Share to Genomics and Chromatin Dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30823889
DOI: 10.1186/s13046-019-1116-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of the cohesin-core subunit SMC1A contributes to colorectal cancer developmentPMID 30823889Read ↗

Mutant cohesin drives chromosomal instability in early colorectal adenomas.Semantic proximity Read ↗

Role of SMC1A overexpression as a predictor of poor prognosis in late stage colorectal cancerSemantic proximity Read ↗

A cohesin cancer mutation reveals a role for the hinge domain in genome organization and gene expression.Semantic proximity Read ↗

Spectrum and consequences of SMC1A mutations: the unexpected involvement of a core component of cohesin in human disease.Semantic proximity Read ↗

Cohesin Mutations in Cancer.Semantic proximity Read ↗

Cohesin gene mutations in tumorigenesis: from discovery to clinical significance.Semantic proximity Read ↗

The expanding universe of cohesin functions: a new genome stability caretaker involved in human disease and cancer.Semantic proximity Read ↗

The multiple facets of the SMC1A gene.Semantic proximity Read ↗

SMC4 Promotes Proliferation and Migration of Colon Adenocarcinoma CellsSemantic proximity Read ↗

NCAPH plays important roles in human colon cancerSemantic proximity Read ↗

Emerging themes in cohesin cancer biology.Semantic proximity Read ↗

Cornelia de Lange syndrome, cohesin, and beyond.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.