Association of Genetic Ancestry and Colorectal Cancer Risk in a Large Brazilian Cohort: Replication of Single-Nucleotide Polymorphisms Identified by Genome-Wide Association Studies.

doi:10.1200/GO-24-00512

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Association of Genetic Ancestry and Colorectal Cancer Risk in a Large Brazilian Cohort: Replication of Single-Nucleotide Polymorphisms Identified by Genome-Wide Association Studies.

JCO global oncology - 1 Jun 2025

de Carvalho Ana Carolina, Laus Ana Carolina, Lopes Junior Howard Ribeiro, Porto Jun, Sant'Anna Silva Débora, Ribeiro Adeylson Guimarães, Datorre José Guilherme, Tavares Rosielly Melo, Sousa Carlos Anne Beatriz, Furquim Tulio, Uno Miyuki, Chammas Roger, Villela Priscilla, Dos Reis Mariana Bisarro, de Medeiros Matsushita Marcus, Oliveira Marco Antônio, Hirai Welinton Yoshio, Guimarães Denise Peixoto, Santos Florinda Almeida, Reis Rui Manuel

Abstract excerpt

PURPOSE: Genome-wide association studies have identified several single-nucleotide polymorphisms (SNPs) linked to colorectal cancer (CRC) risk in European and Asian populations, but studies in admixed populations, like Brazilians, remain scarce. We aimed to replicate 45 SNPs associated with CRC risk and explore their correlation with genetic ancestry in a large Brazilian cohort. METHODS: A case-control study...

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PMID: 40479638
DOI: 10.1200/GO-24-00512

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