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Article

TGFβ1 Genetic Variants Predict Clinical Outcomes of HPV-Positive Oropharyngeal Cancer Patients after Definitive Radiotherapy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2018

Tao Ye, Sturgis Erich M, Huang Zhigang, Wang Ying, Wei Peng, Wang Jennifer Rui, Wei Qingyi, Li Guojun

Abstract excerpt

Purpose: TGFβ1 plays a critical role in inflammation and immune responses and treatment response and survival. TGFβ1 variants may affect its expression level or functional efficiency, thus modifying tumor status and survival in human papillomavirus (HPV)-positive squamous cell carcinoma of the oropharynx (SCCOP).Experimental Design: We determined tumor HPV16 status and genotyped three TGFβ1 polymorphisms in 564...

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Identifiers

PMID: 29463556
DOI: 10.1158/1078-0432.CCR-17-1904
PMCID: PMC5932112

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