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Article

A TGF-β1 genetic variant at the miRNA187 binding site significantly modifies risk of HPV16-associated oropharyngeal cancer.

International journal of cancer - 15 Sept 2018

Tao Ye, Sturgis Erich M, Huang Zhigang, Sun Yan, Dahlstrom Kristina R, Wei Qingyi, Li Guojun

Abstract excerpt

TGF-β1rs1982073 polymorphism at the miRNA-187 binding site may alter TGF-β1 expression and function, and thereby this polymorphism (genotype CT/CC) increases cancer susceptibility. HPV16 L1 seropositivity is associated with the risk of oral squamous cell carcinoma (OSCC), including oropharyngeal squamous cell carcinoma (OPSCC) and oral cavity squamous cell carcinoma (OCSCC). Thus, we hypothesized that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Human papillomavirus 16

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Source

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Identifiers

PMID: 29663347
DOI: 10.1002/ijc.31530
PMCID: PMC6120756

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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