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Article

Protective role of TGF-β1 (-509C>T, rs1800469) single-nucleotide polymorphism against radiation toxicities in locally advanced head and neck cancer.

Indian journal of pathology & microbiology - 1 Jan 2026

Krishnan M P Sarath, Goyal Bela, Gupta Sweety, Christudass Christhunesa S, Solomon Raja, Mirza Anissa A, Gupta Amit, Chaudhary Nitin, Prajapati Ayush, Mistry Satarupa

Abstract excerpt

BACKGROUND: Head and neck cancer (HNC), predominantly head and neck squamous cell carcinoma (HNSCC), poses a significant health burden globally. Intensity-modulated radiation therapy (IMRT) has improved outcomes in HNC; however, radiation-induced toxicities, particularly oral mucositis and dermatitis, remain critical concerns. Genetic variations, such as single-nucleotide polymorphisms (SNPs) in the TGF-β1 gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41913416
DOI: 10.4103/ijpm.ijpm_1085_24

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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