Article
Kelch Mutations in Plasmodium falciparum Protein K13 Do Not Modulate Dormancy after Artemisinin Exposure and Sorbitol Selection In Vitro.
Antimicrobial agents and chemotherapy - 1 May 2018
Breglio Kimberly F, Rahman Rifat S, Sá Juliana M, Hott Amanda, Roberts David J, Wellems Thomas E
Abstract excerpt
Some Kelch mutations of the Plasmodium falciparum K13 protein confer increased survival to dihydroartemisinin (DHA)-treated ring-stage parasites. Here, we asked if K13 mutations affect a dormancy phenotype allowing parasites to survive DHA exposure and then sorbitol selection. Although recrudescence from dormancy differed between two distinct parasite lines, it was similar for isogenic lines carrying single-site...
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