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Article

Lack of K13 mutations in Plasmodium falciparum persisting after artemisinin combination therapy treatment of Kenyan children.

Malaria journal - 22 Jan 2016

Muwanguzi Julian, Henriques Gisela, Sawa Patrick, Bousema Teun, Sutherland Colin J, Beshir Khalid B

Abstract excerpt

BACKGROUND: Studies in Southeast Asia reported a strong relationship between polymorphisms at the propeller domain of the Kelch 13 (K13) protein encoded by the Plasmodium falciparum k13 (pfk13) gene and delayed parasite clearance after artemisinin treatment. In Africa, P. falciparum remains susceptible and combination therapy regimens which include an artemisinin component display good efficacy. Using...

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Identifiers

PMID: 26801909
DOI: 10.1186/s12936-016-1095-y
PMCID: PMC4722670

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