Article
Updates on k13 mutant alleles for artemisinin resistance in Plasmodium falciparum.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi - 1 Apr 2018
Zaw Myo Thura, Emran Nor Amalina, Lin Zaw
Abstract excerpt
BACKGROUND: In the fight against malaria caused by Plasmodium falciparum, the successes achieved by artemisinin were endangered by resistance of the parasites to the drug. Whole genome sequencing approach on artemisinin resistant parasite line discovered k13 gene associated with drug resistance. In vitro and in vivo studies indicated mutations in the k13 gene were linked to the artemisinin resistance....
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