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Plasticity and intratumoural heterogeneity of cell surface antigen expression in breast cancer

20 Feb 2018

Abstract excerpt

Background:The intratumoural heterogeneity, often driven by epithelial-to-mesenchymal transition (EMT), significantly contributes to chemoresistance and disease progression in adenocarcinomas. Methods:We introduced a high-throughput screening platform to identify surface antigens that associate with epithelial–mesenchymal plasticity in well-defined pairs of epithelial cell lines and their mesenchymal...

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PMID: 29462126
DOI: 10.1038/bjc.2017.497

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