Article
Profiling of normal and malignant breast tissue show CD44high/CD24low phenotype as a predominant stem/progenitor marker when used in combination with Ep-CAM/CD49f markers.
BMC cancer - 14 Jun 2013
Ghebeh Hazem, Sleiman Ghida Majed, Manogaran Pulicat S, Al-Mazrou Amer, Barhoush Eman, Al-Mohanna Falah H, Tulbah Asma, Al-Faqeeh Khalid, Adra Chaker N
Abstract excerpt
BACKGROUND: Accumulating evidence supports cancer to initiate and develop from a small population of stem-like cells termed as cancer stem cells (CSC). The exact phenotype of CSC and their counterparts in normal mammary gland is not well characterized. In this study our aim was to evaluate the phenotype and function of stem/progenitor cells in normal mammary epithelial cell populations and their malignant...
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