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Article

Single-cell profiling of surface glycosphingolipids opens a new dimension for deconvolution of breast cancer intratumoral heterogeneity and phenotypic plasticity.

Journal of lipid research - 1 Sept 2024

Procházková Jiřina, Fedr Radek, Hradilová Barbora, Kvokačková Barbora, Slavík Josef, Kováč Ondrej, Machala Miroslav, Fabian Pavel, Navrátil Jiří, Kráčalíková Simona, Levková Monika, Ovesná Petra, Bouchal Jan, Souček Karel

Abstract excerpt

Glycosylated sphingolipids (GSLs) are a diverse group of cellular lipids typically reported as being rare in normal mammary tissue. In breast cancer (BCa), GSLs have emerged as noteworthy markers associated with breast cancer stem cells, mediators of phenotypic plasticity, and contributors to cancer cell chemoresistance. GSLs are potential surface markers that can uniquely characterize the heterogeneity of the...

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Identifiers

PMID: 39084491
DOI: 10.1016/j.jlr.2024.100609
PMCID: PMC11405820

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CD9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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