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Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response

31 Mar 2021

Abstract excerpt

The heterogeneity of breast cancer plays a major role in drug response and resistance and has been extensively characterized at the genomic level. Here, a single-cell breast cancer mass cytometry (BCMC) panel is optimized to identify cell phenotypes and their oncogenic signalling states in a biobank of patient-derived tumour xenograft (PDTX) models representing the diversity of human breast cancer. The BCMC panel...

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PMID: 33790302
DOI: 10.1038/s41467-021-22303-z

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