Article

CD4 <sup>+</sup> T-cells sensitize quasi-mesenchymal breast tumors lacking CD73 to anti-CTLA4 immune checkpoint blockade therapy

2025-05-13

Abstract excerpt

Although immune checkpoint blockade therapy has generated dramatic responses in certain cancer types, breast tumors are largely unresponsive. Epithelial-mesenchymal plasticity leads to the assembly of an immunosuppressive tumor microenvironment and drives resistance of breast tumors to immunotherapies. Importantly, targeting CD73 completely sensitizes quasi-mesenchymal breast tumors to anti-CTLA4 immune checkpoint...

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Literature Corpus work: 49ea6576-2e3b-5f23-9696-cf0c8f943dab
DOI: 10.1101/2025.05.12.653467

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