Multidimensional phenotyping of breast cancer cell lines to guide preclinical research.

doi:10.1007/s10549-017-4496-x

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Multidimensional phenotyping of breast cancer cell lines to guide preclinical research.

Breast cancer research and treatment - 1 Jan 2018

Saunus Jodi M, Smart Chanel E, Kutasovic Jamie R, Johnston Rebecca L, Kalita-de Croft Priyakshi, Miranda Mariska, Rozali Esdy N, Vargas Ana Cristina, Reid Lynne E, Lorsy Eva, Cocciardi Sibylle, Seidens Tatjana, McCart Reed Amy E, Dalley Andrew J, Wockner Leesa F, Johnson Julie, Sarkar Debina, Askarian-Amiri Marjan E, Simpson Peter T, Khanna Kum Kum, Chenevix-Trench Georgia, Al-Ejeh Fares, Lakhani Sunil R

Abstract excerpt

PURPOSE: Cell lines are extremely useful tools in breast cancer research. Their key benefits include a high degree of control over experimental variables and reproducibility. However, the advantages must be balanced against the limitations of modelling such a complex disease in vitro. Informed selection of cell line(s) for a given experiment now requires essential knowledge about molecular and phenotypic context...

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PMID: 28889351
DOI: 10.1007/s10549-017-4496-x

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EGFR

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