Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Propofol exposure during early gestation impairs learning and memory in rat offspring by inhibiting the acetylation of histone

20 Feb 2018

Abstract excerpt

Propofol is widely used in clinical practice, including non-obstetric surgery in pregnant women. Previously, we found that propofol anaesthesia in maternal rats during the third trimester (E18) caused learning and memory impairment to the offspring rats, but how about the exposure during early pregnancy and the underlying mechanisms? Histone acetylation plays an important role in synaptic plasticity. In this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anesthesia and Neurotoxicity Research
Share to Cancer, Stress, Anesthesia, and Immune Response
Share to Intensive Care Unit Cognitive Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29461008
DOI: 10.1111/jcmm.13524

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Propofol exposure during early gestation impairs learning and memory in rat offspring by inhibiting the acetylation of histonePMID 29461008Read ↗

KIF17 mediates the learning and memory impairment in offspring induced by maternal exposure to propofol during middle pregnancy.Semantic proximity Read ↗

The Role of Epigenetic Modifications in Neurotoxicity Induced by Neonatal General AnesthesiaSemantic proximity Read ↗

Neonatal anesthesia and dysregulation of the epigenomeSemantic proximity Read ↗

Role of Histone Deacetylases (HDACs) in Epilepsy and EpileptogenesisSemantic proximity Read ↗

Effect of histone demethylase KDM5B on long-term cognitive impairment in neonatal rats induced by sevofluraneSemantic proximity Read ↗

Epigenetic Mechanisms of Postoperative Cognitive Impairment Induced by Anesthesia and NeuroinflammationSemantic proximity Read ↗

Epigenetic Manipulation of Brain-derived Neurotrophic Factor Improves Memory Deficiency Induced by Neonatal Anesthesia in RatsSemantic proximity Read ↗

Propofol Alters Long Non-Coding RNA Profiles in the Neonatal Mouse Hippocampus: Implication of Novel Mechanisms in Anesthetic-Induced Developmental NeurotoxicitySemantic proximity Read ↗

Neuroprotection by the histone deacetylase inhibitor trichostatin A in a model of lipopolysaccharide-sensitised neonatal hypoxic-ischaemic brain injurySemantic proximity Read ↗

Propofol alleviates PTSD-like behavioral deficits by downregulating hippocampal Arc associated with GABAergic activation in basolateral amygdala in ratsSemantic proximity Read ↗

Oral acetate supplementation attenuates N-methyl D-aspartate receptor hypofunction-induced behavioral phenotypes accompanied by restoration of acetyl-histone homeostasis.Semantic proximity Read ↗

The Epigenetic Changes in a Rat Model of Post-traumatic Stress Disorder Controlled by Valproic AcidSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.