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Article

Epigenetic Manipulation of Brain-derived Neurotrophic Factor Improves Memory Deficiency Induced by Neonatal Anesthesia in Rats

11 Dec 2015

Abstract excerpt

AbstractAbstract The authors found a substantial reduction of hippocampal brain-derived neurotrophic factor resulting from the transcriptional factors–mediated epigenetic modification in the promoter region of Bdnf exon IV in rats exposed postnatally to anesthetic drugs. This brain-derived neurotrophic factor reduction led to the insufficient drive for the synthesis of synaptic proteins, thus contributing to the...

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PMID: 26649423
DOI: 10.1097/aln.0000000000000981

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