Article

The Epigenetic Changes in a Rat Model of Post-traumatic Stress Disorder Controlled by Valproic Acid

2023-10-03

Abstract excerpt

Valproic acid (VPA) is a potent non-selective histone deacetylase (HDAC) inhibitor. HDAC inhibitors and histone proteins have been studied extensively in the literature. They have been proven effective in the learning and memory processes in psychiatric conditions, including post-traumatic stress disorder (PTSD). However, the exact mechanisms and significance of different epigenetic modulations are far less clarif...

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Literature Corpus work: c65da537-dfea-57f2-b1c8-b44d3522398b
DOI: 10.21203/rs.3.rs-3345021/v1

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