Article

Propofol alleviates PTSD-like behavioral deficits by downregulating hippocampal Arc associated with GABAergic activation in basolateral amygdala in rats

2022-12-19

Abstract excerpt

<title>Abstract</title><p>Propofol (2,6-diisopropylphenol) is one of the most commonly used anesthetics in clinical surgery. However, its role and relevant mechanisms in post-traumatic stress disorder (PTSD)-like behavioral deficits remain largely unknown. In this study, the PTSD-like phenotype was constructed in rats using the modified single prolonged stress (MSPS) procedure. Propofol and GABAergic system antago...

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Literature Corpus work: d34e5d32-855b-596d-a0aa-b2a52fd08fbb
DOI: 10.21203/rs.3.rs-2349261/v1

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